Boost Your NAD and brain with keto diet, MCT, and exogenous ketones

In a recent podcast episode, I spoke with Dr. Dom D'Agostino, an expert in ketogenic diets and metabolic therapies. Dr. D'Agostino, an associate professor at the University of South Florida and a research scientist at the Institute for Human and Machine Cognition, focuses on metabolic strategies for central nervous system disorders.

Here are the key takeaways from our discussion.

Watch the full episode here: https://www.youtube.com/watch?v=srhbO31D-g0

Understanding NAD and Its Importance

NAD (Nicotinamide Adenine Dinucleotide) is a vital molecule in the body that participates in energy production, metabolism, longevity and anti-aging processes. While calorie restriction and fasting can boost NAD levels, a ketogenic diet also effectively increases NAD by enhancing the citric acid cycle.

Ketogenic Diets and NAD Levels

A ketogenic diet induces a metabolic state called ketosis, where the body shifts from using glucose to using ketones for energy. This metabolic switch not only elevates NAD levels but also improves brain energy metabolism and reduces inflammation, offering potential benefits for overall health and longevity.

The Role of Ketones in Brain Health

Ketones are fatty acids produced in the body. They provide an alternative energy source for the brain in oppose to glucose. They're particularly beneficial in conditions where glucose levels in the blood are low, such as during fasting or intense exercise. Impaired brain glucose metabolism (hypometabolism) is also seen in Alzheimer’s disease. Ketones, especially beta-hydroxybutyrate, enhance brain energy metabolism, reduce inflammation, and help mitigate the effects of neurodegenerative diseases.

Differences Between Ketones and Nutritional Ketosis

Nutritional ketosis is achieved through a ketogenic diet, whereas exogenous ketones are obtained from supplements. Both forms offer benefits, but their applications can vary depending on individual needs and health goals.

Cognitive Enhancement Through Ketones

Acute ketosis, achieved via fasting or exogenous ketones, can improve mental clarity and focus, especially under stress or sleep deprivation. This makes ketones a valuable tool for those experiencing brain fog or seeking cognitive enhancement.

Practical Steps to Incorporate Ketones

One way to induce a ketogenic state is a ketogenic diet, but it's hard. To harness the benefits of ketones without committing to a full ketogenic diet, consider a low-carb, whole-foods diet, such as a low-carb Mediterranean diet. Then, incorporate medium-chain triglycerides (MCTs) into meals and consider using ketone salts or esters for immediate benefits. These are supplements that can be bought in almost any supplement store. Look for C8 oil or MCT oil.

Download a free supplement guide for more brain-healthy supplements.

Insights on Metformin

Metformin, commonly used for type 2 diabetes, helps lower blood glucose and reduce inflammation but acts as a mild mitochondrial toxin. While it can reduce cancer risk and enhance metabolic health, its use should be carefully monitored.

Conclusion

Optimizing NAD and ketone levels through diet and supplementation can significantly enhance well-being and potentially extend lifespan. For more in-depth insights, listen to the full podcast episode and share your thoughts and questions in the YouTube comments.

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Timestamps

• 02:25 - Dom's background in ketone research
• 05:20 - What are ketones, nutritional ketosis, and exogenous ketones
• 09:00 - Ketones & building muscle
• 12:00 - Seizures, Alzheimer's, inflammation, and brain energy
• 16:40 - Mental health benefits, stress reduction, GABA
• 20:50 - Prevent cancer growth
• 22:00 - Products: LMNT, Ketostart (L-BHB vs DL-BHB)
• 23:40 - Longevity & NAD boosting
• 25:35 - Alzheimer's & reversing dementia
• 30:10 - Can coconut oil, MCT oil, and C8 oil
• 35:40 - Genetic disorders & gene expression
• 36:35 - Smart drugs, cognitive enhancement, brain fog
• 39:20 - Glucose hypometabolism and metabolic control, improve energy production
• 41:08 - Do ketones work for the average person?
• 42:50 - How to start to benefit from ketones? Diet vs supplements
• 46:14 - Products: Ketostart, LMNT, Keto Brainz
• 48:49 - Metformin for blood glucose and health
• 53:50 - Dom D'Agostino links